Cardiovascular Mechanics Simulation

Multiscale computational modeling of cardiac structure, function, and disease mechanisms

Figure: The steps of a published study on Silent Myocardial Infarction (Courtesy: Md. Shah Wali Ullah, Samayala Rahman Oyshie)

This research aims to develop multiscale computational models of the human heart to investigate the underlying mechanisms of major cardiac diseases and to evaluate treatment strategies.

One ongoing project investigates how small, regionally distributed myocardial infarction zones located within the thin transmural layers of the left ventricular wall alter the global ventricular mechanics and pumping efficiency.

Another project examines how mitral regurgitation and aortic stenosis interact with hypertrophic cardiomyopathy, using a finite-element modeling framework to quantify the resulting changes in wall stress, ventricular remodeling, and hemodynamics.

The latest projects are:

  1. Attempting to quantify ventricular-arterial coupling in HFPEF patients using a coupled left-ventricular and aortic finite-element modeling framework modeling
  2. Investigating the effect of bi-directional ventricular-arterial mechanics in aortic aneurysm.

Together, these efforts will provide mechanistic insights that support improved diagnosis, patient-specific risk assessment, and optimization of treatment methods.